Key result
During hypoxia, acute acidosis resulted in a more pronounced rise in pulmonary vascular resistance than acute alkalosis (P < 0.01).
Why the study?
Do acutely induced changes in arterial pH alter pulmonary vascular resistance during normoxia and hypoxia in awake dogs?
Population
Awake dogs with chronically implanted catheters and electromagnetic flow probe
Comparison
Acutely induced changes in arterial pH via slow… vs Baseline state and comparison between acidosis…
Design
Preclinical
Authors
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Acute acidosis augments hypoxic PVR rise versus alkalosis in awake dogs; leaves open translation to human hypoxic lung disease.
Do acutely induced changes in arterial pH alter pulmonary vascular resistance during normoxia and hypoxia in awake dogs?
p-value: p=< 0.01
In awake dogs, acute alkalosis decreases pulmonary vascular resistance and blunts hypoxic vasoconstriction, whereas mild acidosis increases pulmonary vascular resistance and enhances hypoxic vasoconstriction.
Thilenius et al. (1972) studied Normoxia and hypoxia. Acute acidosis and acute alkalosis vs. Baseline/each other was evaluated on Pulmonary vascular resistance during hypoxia (p=< 0.01). During hypoxia, acute acidosis resulted in a more pronounced rise in pulmonary vascular resistance than acute alkalosis (P < 0.01).
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