Key result
Oleic acid markedly increases lobe weight gain versus saline in preclinical models.
Why the study?
Does oleic acid induce dose-related pulmonary edema in isolated canine lungs perfused at constant pressure?
Does oleic acid induce dose-related pulmonary edema in isolated canine lungs perfused at constant pressure?
Absolute Event Rate: 0.6% vs 0.13%
Oleic acid induces dose-dependent pulmonary edema in isolated canine lungs even at constant perfusion pressure, suggesting a direct effect on vascular permeability.
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Preclinical only; extends dose-dependency data on permeability edema but leaves open in vivo or clinical relevance.
Ehrhart et al. (1981) studied Pulmonary edema (n=19). Oleic acid vs. Saline was evaluated on Total lobe weight gain (g/g initial lobe wt). Oleic acid administration at 45 and 1 microliter/kg increased total lobe weight gain compared to saline controls (0.60 and 0.31 vs 0.13 g/g initial lobe wt, respectively).
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