Key result
In dogs with oleic acid-induced pulmonary edema, minoxidil significantly increased lung water by 60% compared to 27% in untreated animals (P<0.05) and worsened venous admixture.
Why the study?
Does vasodilator treatment with hydralazine or minoxidil affect gas exchange and lung water accumulation in dogs with oleic acid-induced pulmonary edema?
Population
30 dogs with stable, diffuse lung injury produced by intravenous oleic acid 1 day prior to study.
Comparison
Minoxidil or hydralazine over a 5-hour period. vs Untreated animals.
Design
Preclinical
Follow-up
5 hours
Authors
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Supports caution with minoxidil in permeability edema; leaves open vasodilator effects in human acute lung injury.
Does vasodilator treatment with hydralazine or minoxidil affect gas exchange and lung water accumulation in dogs with oleic acid-induced pulmonary edema?
p-value: p=<0.05
In a canine model of permeability pulmonary edema, peripheral vasodilators worsened gas exchange and increased lung water, with the severity depending on the drug's effect on pulmonary circulation.
Bishop et al. (1986) studied Canine oleic acid-induced pulmonary edema (n=30). Minoxidil or Hydralazine vs. Untreated was evaluated on Venous admixture and lung water accumulation (p=<0.05). In dogs with oleic acid-induced pulmonary edema, minoxidil significantly increased lung water by 60% compared to 27% in untreated animals (P<0.05) and worsened venous admixture.
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