Key result
Hyperglycemia significantly impaired coronary arteriolar dilation during increased myocardial oxygen consumption compared to normal dogs (16% vs 36% change in diameter, P<0.05).
Population
Normal and hyperglycemic (1 week alloxan, 60 mg/kg iv) dogs
Comparison
Hyperglycemia with administration of… vs Normal dogs
Design
Preclinical
Authors
Loading...
Hyperglycemia may alter coronary microvascular dilation in dogs; leaves open relevance to human endothelial dysfunction.
Absolute Event Rate: 16% vs 36%
p-value: p=<0.05
Hyperglycemia selectively impairs coronary arteriolar dilation in response to endothelium-dependent vasodilators and increased myocardial oxygen consumption, an effect that can be restored by superoxide dismutase or thromboxane A2/prostaglandin H2 receptor antagonism.
Ammar et al. (2000) studied Hyperglycemia (n=19). Hyperglycemia vs. Normal dogs was evaluated on Change in coronary arteriolar diameter during dobutamine and rapid atrial pacing (p=<0.05). Hyperglycemia significantly impaired coronary arteriolar dilation during increased myocardial oxygen consumption compared to normal dogs (16% vs 36% change in diameter, P<0.05).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: