Population
33 dogs, anesthetized with pentobarbital and pretreated with aspirin.
Comparison
Acetylcholine and adenosine infusion, with… vs Vehicle-treated non-diabetic dogs.
Design
Preclinical
Authors
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Impaired ACh-mediated coronary vasodilation in diabetic dogs should not change practice; leaves open L-arginine effects on human endothelial function.
Endothelium-derived nitric oxide regulation of coronary blood flow is impaired in alloxan-induced diabetic dogs, an impairment that can be partially restored by L-Arginine.
Matsunaga et al. (1996) studied this question.
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