What question did this study set out to answer?

To examine the influence of experimental diabetes on endothelium-dependent vasodilation and cyclic GMP release within the coronary arterial bed.

April 1, 1997Cardiovascular ResearchOpen Access

Characteristics of coronary endothelial dysfunction in experimental diabetes

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Why the study?

Does experimental diabetes impair endothelium-dependent vasodilation in the coronary arterial bed of dogs?

Population

Healthy and diabetic dogs

Comparison

Administration of acetylcholine, L-arginine… vs Healthy control dogs

Design

Preclinical

Authors

MKMaria Zsófia KoltaiGottsegen National Cardiovascular Center

Discussion

Member takes

Implication

Animal models of diabetes highlight potential coronary endothelial impairment; leaves open translation to human disease and NO-targeted therapies.

Key Points

To examine the influence of experimental diabetes on endothelium-dependent vasodilation and cyclic GMP release within the coronary arterial bed.
Measured coronary conductivity, vascular tone, and cGMP release (via radioimmunoassay) in healthy and diabetic dogs in vivo and in isolated coronary artery preparations.
Tested vascular responses to acetylcholine, L-arginine, and sodium nitroprusside before and after cyclo-oxygenase inhibition.
Acetylcholine-mediated coronary conductivity increases were significantly reduced in diabetic dogs in vivo (P < 0.01), with no cGMP release increase observed in isolated diabetic coronaries (P < 0.05) even after L-arginine addition (P < 0.05).
Cyclo-oxygenase inhibition further impaired acetylcholine responsiveness in vivo (P < 0.01) and in isolated diabetic coronary strips, while relaxation to sodium nitroprusside remained unaltered across groups.

Structured PICO

Does experimental diabetes impair endothelium-dependent vasodilation in the coronary arterial bed of dogs?

Population

Healthy and diabetic dogs

Intervention

Administration of acetylcholine, L-arginine, sodium nitroprusside, and cyclo-oxygenase inhibition

Comparator

Healthy control dogs

Outcome

Coronary conductivity, vascular tone, and cGMP releasesurrogate

Experimental diabetes impairs coronary vasodilation through defective endothelial nitric oxide production and action, which is not sufficiently compensated by vasodilating prostanoids.

Cite This Study

Maria Zsófia Koltai (1997) studied this question.

synapsesocial.com/papers/6a8aa5720a8dc73d8e3322cc https://doi.org/10.1016/s0008-6363(97)00050-3

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Implication

Animal models of diabetes highlight potential coronary endothelial impairment; leaves open translation to human disease and NO-targeted therapies.

Characteristics of coronary endothelial dysfunction in experimental diabetes

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Characteristics of coronary endothelial dysfunction in experimental diabetes

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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