Why the study?
Does experimental diabetes alter endothelium-mediated relaxation and contractile responses in canine coronary arteries?
Population
Canine isolated coronary arteries from alloxan-treated diabetic (280 mmol·kg−1) and control mongrel dogs (n=7)
Comparison
Experimental diabetes (alloxan-induced) vs Non-diabetic control mongrel dogs
Design
Preclinical
Authors
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Does not support clinical changes; hypothesis-generating for diabetic coronary reactivity and requires human validation.
Does experimental diabetes alter endothelium-mediated relaxation and contractile responses in canine coronary arteries?
Experimental diabetes impairs the response to endothelium-derived relaxing factor and non-specifically increases the maximal contractile response of coronary arterial smooth muscle to prostaglandin F2α in a canine model.
Gebremedhin et al. (1988) studied this question.
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