What question did this study set out to answer?

To evaluate the effect of chronic diabetes mellitus on left ventricular performance and coronary blood flow during acute myocardial ischemia.

June 1, 1977Circulation Research

Myocardial function and coronary blood flow response to acute ischemia in chronic canine diabetes.

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Why the study?

Does preexistent diabetes mellitus worsen left ventricular performance and coronary blood flow responses to acute ischemia in a canine model?

Population

19 mongrel dogs (9 with alloxan-induced mild normoglycemic diabetes, 10 nondiabetic controls)

Comparison

Acute ischemia produced by occlusion of the… vs Nondiabetic control dogs undergoing the same…

Design

Preclinical

Follow-up

1 hour of ischemia

Authors

BHB HaiderQueen Fabiola Children's University Hospital SAShafiuddin AhmedRutgers, The State University of New Jersey CMChristos B. MoschosRutgers, The State University of New Jersey

Discussion

Member takes

Implication

Diabetes exacerbates early ischemic LV dysfunction in canines; hypothesis-generating for human translation.

Key Points

To evaluate the effect of chronic diabetes mellitus on left ventricular performance and coronary blood flow during acute myocardial ischemia.
Mild normoglycemic diabetes was induced in 9 mongrel dogs via three monthly alloxan injections (20 mg/kg, iv) and compared to 10 nondiabetic control dogs.
Acute ischemia was induced by balloon-catheter occlusion of the proximal left anterior descending coronary artery under anesthesia.
Hemodynamics, coronary blood flow (85Kr clearance), ischemic zone size, tissue electrolytes, metabolites, and morphology were evaluated.
During the first hour of ischemia, end-diastolic pressure rose from 7 ± 1.1 to 23.8 ± 2.3 mm Hg in diabetic dogs without end-diastolic volume expansion, whereas controls increased from 8.6 ± 1.1 to 15.3 ± 1.4 mm Hg with significant volume expansion, resulting in a higher pressure-to-volume ratio in diabetics (P < 0.005).
Reductions in stroke volume and stroke work were significantly greater in diabetic animals despite equivalent reductions in coronary blood flow, similar ischemic area size, and comparable tissue potassium loss and sodium gain.
Diabetic ischemic myocardium maintained elevated triglyceride levels and showed diffuse interstitial accumulation of periodic acid-Schiff-positive glycoprotein.

Structured PICO

Does preexistent diabetes mellitus worsen left ventricular performance and coronary blood flow responses to acute ischemia in a canine model?

Population

19 mongrel dogs (9 with alloxan-induced mild normoglycemic diabetes, 10 nondiabetic controls)

Intervention

Acute ischemia produced by occlusion of the proximal left anterior descending coronary artery via a balloon-type catheter

Comparator

Nondiabetic control dogs undergoing the same acute ischemia protocol

Outcome

Left ventricular performance (end-diastolic pressure, end-diastolic volume, stroke volume, work) and coronary blood flow responses to acute ischemiasurrogate

Preexistent diabetes in a canine model exacerbates the reduction in ventricular performance during acute ischemia, likely due to interstitial glycoprotein accumulation limiting diastolic filling.

Cite This Study

Haider et al. (1977) studied this question.

synapsesocial.com/papers/6a7262bde5469ee92be2633c https://doi.org/10.1161/01.res.40.6.577

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Myocardial function and coronary blood flow response to acute ischemia in chronic canine diabetes.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Myocardial function and coronary blood flow response to acute ischemia in chronic canine diabetes.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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