Key result
Chronic diabetes mellitus in dogs altered myocardial composition and function, including increased left ventricular stiffness and triglyceride accumulation, independent of vascular effects.
Why the study?
Does chronic diabetes mellitus alter myocardial function and metabolism independent of ischemia in dogs?
Population
Male mongrel dogs
Comparison
Mild noninsulin-requiring diabetes produced by… vs Normal control dogs and dogs where pancreatic…
Design
Preclinical
Follow-up
approximately 11 months
Authors
Loading...
Does not support practice change; leaves open translation of direct myocardial effects to human diabetic cardiomyopathy.
Does chronic diabetes mellitus alter myocardial function and metabolism independent of ischemia in dogs?
Chronic diabetes mellitus can directly alter myocardial composition and function, leading to increased ventricular stiffness and altered lipid metabolism, independent of coronary atherosclerosis.
Regan et al. (1974) studied Chronic diabetes mellitus without ischemia. Alloxan-induced chronic diabetes mellitus vs. Normal control dogs was evaluated on Myocardial composition and function (hemodynamic and metabolic studies). Chronic diabetes mellitus in dogs altered myocardial composition and function, including increased left ventricular stiffness and triglyceride accumulation, independent of vascular effects.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: