Key result
Alloxan-induced diabetes (100 mg/kg) in rabbits resulted in myocardial ultrastructural abnormalities at 10 weeks, most prominently swollen and fragmented mitochondria with distorted cristae.
Population
Rabbits with alloxan-induced diabetes
Design
Preclinical
Follow-up
10 weeks
Authors
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Mitochondrial injury may contribute to diabetic cardiomyopathy in this model; leaves open relevance to human disease and needs prospective validation.
Alloxan-induced diabetes in rabbits leads to significant myocardial ultrastructural abnormalities, particularly mitochondrial damage, which may contribute to diabetic cardiomyopathy.
Bhimji et al. (1986) studied Alloxan-induced diabetes. Alloxan was evaluated on Myocardial ultrastructural changes. Alloxan-induced diabetes (100 mg/kg) in rabbits resulted in myocardial ultrastructural abnormalities at 10 weeks, most prominently swollen and fragmented mitochondria with distorted cristae.
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