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November 1, 1984Arteriosclerosis An Official Journal of the American Heart Association IncOpen Access

Atherosclerosis and myocardial ischemic lesions in alloxan-diabetic rabbits fed a low cholesterol diet.

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Why the study?

Does alloxan-induced diabetes exacerbate atherosclerosis and myocardial ischemic lesions in rabbits fed a low cholesterol atherogenic diet?

Population

Alloxan-diabetic, alloxan-nondiabetic, and control rabbits

Comparison

Low cholesterol atherogenic diet for up to 40… vs Alloxan-nondiabetic and control rabbits fed the…

Design

Preclinical

Follow-up

up to 40 weeks

Authors

RMRalph MillerSaint Michael's Medical CenterRWRichard B. WilsonUniversity of California, Riverside

Discussion

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Implication

Extends diabetic atherosclerosis models to low-cholesterol diets in rabbits; leaves open translation to human disease.

Structured PICO

Does alloxan-induced diabetes exacerbate atherosclerosis and myocardial ischemic lesions in rabbits fed a low cholesterol atherogenic diet?

P
Population
Alloxan-diabetic, alloxan-nondiabetic, and control rabbits
I
Intervention
Low cholesterol atherogenic diet for up to 40 weeks
C
Comparator
Alloxan-nondiabetic and control rabbits fed the same diet
O
Outcome
Atherosclerosis extent and incidence of myocardial ischemic lesionssurrogate

In contrast to earlier studies with high cholesterol diets, alloxan-diabetic rabbits fed a low cholesterol diet develop more extensive atherosclerosis and ischemic myocardial lesions than nondiabetic controls.

Cite This Study

Miller et al. (1984) studied this question.

synapsesocial.com/papers/6a94cd45a15fb1352cb2bef0https://doi.org/10.1161/01.atv.4.6.586
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Atherosclerosis in rabbits fed a low cholesterol diet for five years.1982 · 58 citations
  2. 2Growth of Rabbit Aortic Smooth-Muscle Cells Cultured in Media Containing Diabetic and Hyperlipemic Serum1976 · 71 citations
  3. 3Effect of insulin on the proliferation of cultured primate arterial smooth muscle cells.1975 · 407 citations
  4. 4THE EFFECT OF ALLOXAN DIABETES ON EXPERIMENTAL CHOLESTEROL ATHEROSCLEROSIS IN THE RABBIT1954 · 79 citations
  5. 5THE MECHANISM OF ALLOXAN PROTECTION IN EXPERIMENTAL ATHEROSCLEROSIS1954 · 34 citations