Why the study?
Does insulin therapy reverse the inhibition of experimental aortic atherosclerosis in alloxan-diabetic rabbits fed cholesterol?
Population
Alloxan-diabetic rabbits fed cholesterol (with or without vegetable oil supplementation)
Comparison
Insulin therapy vs Untreated alloxan-diabetic rabbits fed…
Design
Preclinical
Authors
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Insulin may abolish diabetes-induced protection against atherosclerosis in rabbits; leaves open relevance to human diabetic cardiovascular disease.
Does insulin therapy reverse the inhibition of experimental aortic atherosclerosis in alloxan-diabetic rabbits fed cholesterol?
Insulin therapy reverses the protective effect of alloxan-induced diabetes against cholesterol-induced aortic atherosclerosis in rabbits, indicating the protection is due to the diabetic state rather than alloxan toxicity.
Duff et al. (1954) studied this question.
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