Severe Hypertriglyceridemia, large lipoproteins and protection against atherosclerosis
Population
Alloxan-diabetic cholesterol-fed rabbits and humans with familial lipoprotein lipase deficiency, familial…
Design
Review
Authors
Discussion
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Implication
Hypothesis-generating for reduced atherogenicity of very large lipoproteins; leaves open implications for risk assessment and lipid management.
Structured PICO
P
Population
Alloxan-diabetic cholesterol-fed rabbits and humans with familial lipoprotein lipase deficiency, familial apolipoprotein C-II deficiency, and insulin-dependent diabetes mellitus in the ketoacidotic state
I
Intervention
Severe hypertriglyceridemia with large lipoproteins (diameter ≥ 75 nm)
O
Outcome
Atherosclerosis development / atherogenicity
Cholesterol carried in very large lipoproteins may be less atherogenic due to physical inability to penetrate the arterial endothelium.
Cite This Study
Nordestgaard et al. (1987) studied this question.