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Homozygous WHHL rabbits, an animal model for familial hypercholesterolemia, exhibit both hypercholesterolemia and hypertriglyceridemia, characterized by elevated levels of apolipoprotein B-100 and apolipoprotein E across VLDL, IDL, and LDL fractions. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

November 1, 1982Arteriosclerosis An Official Journal of the American Heart Association IncOpen Access

Concentration and composition of lipoproteins in blood plasma of the WHHL rabbit. An animal model of human familial hypercholesterolemia.

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Authors

RHRichard J. HavelPreventive Cardiology TKTomoko KitaKyoto University LKL KotiteDartmouth College

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Implication

WHHL rabbits mirror human FH lipoprotein defects; confirms model validity but leaves open clinical translation.

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Key points are not available for this paper at this time.

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Havel et al. (1982) studied this question.

synapsesocial.com/papers/6a1dd08049e88a0d41602c1c https://doi.org/10.1161/01.atv.2.6.467

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Concentration and composition of lipoproteins in blood plasma of the WHHL rabbit. An animal model of human familial hypercholesterolemia.

Discussion

Member takes

Implication

Key Points

Cite This Study

Concentration and composition of lipoproteins in blood plasma of the WHHL rabbit. An animal model of human familial hypercholesterolemia.

Discussion

Member takes

Implication

Key Points

Cite This Study

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