Key result
WHHL rabbits maintain normal VLDL apolipoprotein and lipid ratios, unlike diet-induced hypercholesterolemic rabbits.
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Reveals distinct lipoprotein and apolipoprotein compositions in Watanabe Heritable Hyperlipidemic versus cholesterol-fed rabbits, highlighting divergent mechanisms underlying their hyperlipidemia.
The Watanabe Heritable Hyperlipidemic rabbit (WHHL rabbit) and the cholesterol-fed rabbit have been reported to show elevations of very low density (VLDL), intermediate density (IDL), and low density lipoproteins (LDL), and a broad-beta band on agarose-gel electrophoresis. We have studied the lipid and lipoprotein composition of WHHL rabbits and cholesterol-fed rabbits using ultracentrifugal analysis and isoelectric focusing. The total cholesterol (TC)/triglyceride (TG) ratios of VLDL, IDL, and LDL in WHHL rabbits were slightly elevated, but almost normal compared with those of cholesterol-fed rabbits, whose TC/TG ratios were markedly elevated compared with normolipidemic rabbits. ApoVLDL of WHHL rabbits showed no compositional changes in apoE and apoC isoforms, and no marked changes in the apoE/apoC ratios. But apoVLDL of cholesterol-fed rabbits showed a significant decrease of apoC-III, a significant increase of apoC-V, and marked elevation of the apoE/apoC ratio. We conclude that serum lipoprotein compositions in the WHHL rabbit were normal, while the lipoprotein lipid and apolipoprotein composition in the WHHL rabbit are different from those in cholesterol-fed rabbits.
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WAKASUGI et al. (1984) studied Hyperlipidemia. Watanabe Heritable Hyperlipidemic (WHHL) rabbit phenotype vs. Cholesterol-fed rabbits and normolipidemic rabbits was evaluated on Lipid and apolipoprotein composition of VLDL, IDL, and LDL (TC/TG ratios and apoE/apoC isoform ratios). WHHL rabbits had normal apoVLDL apoE/apoC ratios and nearly normal TC/TG ratios, unlike cholesterol-fed rabbits which had decreased apoC-III, increased apoC-V, and elevated apoE/apoC ratios.
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