Why the study?
Does alloxan protect against experimental atherosclerosis through mechanisms independent of the pancreas in cholesterol-fed rabbits?
Population
Rabbits fed cholesterol
Comparison
Alloxan injection vs Control rabbits fed cholesterol
Design
Preclinical
Authors
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Confirms pancreatic mediation of alloxan protection in this rabbit model; leaves open translation to other species or clinical atherosclerosis.
Does alloxan protect against experimental atherosclerosis through mechanisms independent of the pancreas in cholesterol-fed rabbits?
The protective effect of alloxan against experimental atherosclerosis in rabbits is mediated through its diabetogenic action on the pancreas, rather than direct effects on other tissues.
Cook et al. (1954) studied this question.
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