Why the study?
Does alloxan-induced diabetes alter blood pressure and pressor responses in normotensive and spontaneously hypertensive rats?
Does alloxan-induced diabetes alter blood pressure and pressor responses in normotensive and spontaneously hypertensive rats?
Alloxan-induced diabetes produces divergent blood pressure effects in normotensive versus hypertensive rats and reduces in vivo pressor responsiveness, likely due to circulatory factors.
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Should not guide clinical BP management in diabetes; leaves open divergent vascular responses in hypertensive models for translational study.
Cavaliere et al. (2008) studied this question.
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