Why the study?
Does alloxan-induced diabetes or fasting alter cardiac function and myosin ATPase activity in isolated rat hearts?
Population
Isolated rat hearts
Comparison
Alloxan-induced diabetes or fasting for 4 days vs Lower doses of alloxan or baseline/control
Design
Preclinical
Follow-up
Up to 1-2 weeks
Authors
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These rat findings should not change practice; leaves open thyroid hormone modulation in diabetic cardiomyopathy.
Does alloxan-induced diabetes or fasting alter cardiac function and myosin ATPase activity in isolated rat hearts?
Severe experimental diabetes and fasting depress myocardial function and myosin ATPase activity in rats, which is associated with reduced thyroid hormone levels.
Garber et al. (1983) studied this question.
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