Key result
Spontaneous diabetes in BB/W rats leads to significantly depressed calcium-stimulated and actin-activated myosin ATPase activity and a shift in isomyosin content from V1 to V3 isoenzyme.
Why the study?
Does spontaneous diabetes alter cardiac myosin biochemistry in the Bio-Breeding Worcester rat model?
Does spontaneous diabetes alter cardiac myosin biochemistry in the Bio-Breeding Worcester rat model?
Spontaneous diabetes in the BB/W rat model leads to depressed cardiac myosin enzymatic activity and a shift in isomyosin content, independent of thyroid function.
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Hypothesis-generating for myosin dysfunction in diabetic cardiomyopathy; leaves open human relevance and clinical translation.
Malhotra et al. (1985) studied Diabetes. Spontaneous diabetes vs. Age-matched BB/W rats bred for resistance to diabetes was evaluated on Cardiac myosin biochemistry (calcium-stimulated myosin ATPase activity, actin-activated myosin ATPase, isomyosin content). Spontaneous diabetes in BB/W rats leads to significantly depressed calcium-stimulated and actin-activated myosin ATPase activity and a shift in isomyosin content from V1 to V3 isoenzyme.
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