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December 1, 1981Circulation ResearchOpen Access

The effect of streptozotocin-induced diabetes in rats on cardiac contractile proteins.

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Why the study?

Does streptozotocin-induced diabetes alter cardiac contractile protein ATPase activity in rats?

Population

Male and female rats

Comparison

Intravenous streptozotocin to induce diabetes vs Non-diabetic rats, rats pretreated with…

Design

Preclinical

Follow-up

Up to 2 weeks

Authors

AMAshwani MalhotraAlbert Einstein College of MedicineSPS. PenpargkulAlbert Einstein College of MedicineFFFrederick S. FeinWinthrop-University Hospital

Discussion

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Implication

May impair rat cardiac contractility via ATPase; leaves open myosin isoform role and human translation.

Structured PICO

Does streptozotocin-induced diabetes alter cardiac contractile protein ATPase activity in rats?

P
Population
Male and female rats
I
Intervention
Intravenous streptozotocin (STZ) to induce diabetes
C
Comparator
Non-diabetic rats (including food-restricted controls), rats pretreated with 3-O-methyl glucose, thyroidectomized rats, and diabetic rats with thyroid replacement
O
Outcome
Calcium ATPase activity of cardiac actomyosinsurrogate

Streptozotocin-induced diabetes in rats causes a significant decrease in cardiac contractile protein ATPase activity, which may be related to altered proportions of myosin isoenzymes.

Cite This Study

Malhotra et al. (1981) studied this question.

synapsesocial.com/papers/6a7ae38d8d250a4360f43e89https://doi.org/10.1161/01.res.49.6.1243

Topics

Cardiomyopathy
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Diabetes Mellitus Induces Changes in Cardiac Myosin of the Rat1980 · 291 citations
  2. 2Noninvasive Estimation of Myocardial Performance in Patients with Diabetes: Effect of Alcohol Administration1978 · 69 citations
  3. 3ATPase Activity of Myosin Correlated with Speed of Muscle Shortening1967 · 1,986 citations
  4. 4Altered myocardial mechanics in diabetic rats.1980 · 361 citations
  5. 5Effect of the thyroid state on the enzymatic characteristics of cardiac myosin. A difference in behavior of rat and rabbit cardiac myosin.1975 · 128 citations