Why the study?
Does insulin treatment affect cardiac sarcoplasmic reticular calcium transport and heart function in spontaneously diabetic BB rats?
Population
Spontaneously diabetic BB rats (a model of insulin-dependent diabetes)
Comparison
Low and high insulin dose for 12 weeks vs BB nondiabetic littermates or Wistar controls
Design
Preclinical
Follow-up
12 weeks
Authors
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Insulin treatment yielded no cardiac SR Ca2+ differences in diabetic BB rats; hypothesis-generating and should not yet inform human diabetic cardiomyopathy management.
Does insulin treatment affect cardiac sarcoplasmic reticular calcium transport and heart function in spontaneously diabetic BB rats?
In spontaneously diabetic BB rats, 12 weeks of low or high dose insulin treatment did not result in significant diabetes-related differences in cardiac function or SR calcium transport compared to nondiabetic controls.
Rodrigues et al. (1989) studied this question.
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