Why the study?
Does metabolic control (assessed by gHb) affect in vivo myocardial contractile function in response to dobutamine in spontaneously diabetic BB Wor rats?
Does metabolic control (assessed by gHb) affect in vivo myocardial contractile function in response to dobutamine in spontaneously diabetic BB Wor rats?
Poor metabolic control (higher gHb) in insulin-dependent diabetic rats is inversely correlated with myocardial contractile function in response to beta-adrenergic stimulation.
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Poor glycemic control may impair beta-adrenergic responsiveness in diabetic rat myocardium; leaves open translation to human diabetic cardiomyopathy.
Broderick et al. (1994) studied this question.
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