Population
Streptozotocin-diabetic rats
Comparison
Streptozotocin-induced diabetes evaluated at 2… vs Control rats
Design
Preclinical
Follow-up
4 weeks
Authors
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Hypothesis-generating for time-dependent beta-adrenergic impairment in diabetic cardiomyopathy; leaves open translation to human disease.
In a diabetic rat model, alterations in beta-adrenergic receptors and adenylate cyclase coupling emerge after 4 weeks, suggesting a mechanism for the development of diabetic cardiomyopathy.
Atkins et al. (1985) studied this question.
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