Impairment of cardiac alpha 1-adrenoceptor signaling is associated with the diabetic state and may be linked to abnormal activation of cardiac PKC, providing mechanistic insight into diabetic cardiomyopathy.
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Hypothesis-generating for PKC-mediated alpha1-AR impairment in diabetic cardiomyopathy; leaves open human translation.
Tanaka et al. (1992) studied this question.
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