What does this research mean for the field?

Experimental diabetes induces functional activation of protein kinase C epsilon (PKCε) and increased phosphorylation of Troponin I in the heart, which can be completely prevented by insulin or angiotensin II type-1 receptor blockade. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

December 1, 1997Circulation Research

Experimental Diabetes Is Associated With Functional Activation of Protein Kinase Cε and Phosphorylation of Troponin I in the Heart, Which Are Prevented by Angiotensin II Receptor Blockade

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Why the study?

Does AT1 receptor blockade or insulin prevent PKC activation and TnI phosphorylation in cardiocytes of diabetic rats?

Structured PICO

Does AT1 receptor blockade or insulin prevent PKC activation and TnI phosphorylation in cardiocytes of diabetic rats?

Population

Rats made diabetic with a single injection of streptozotocin

Intervention

Insulin (to render euglycemic) or specific angiotensin II type-1 receptor (AT1) antagonist

Comparator

Nondiabetic control rats and untreated diabetic rats

Outcome

Subcellular distribution of PKC isoforms (epsilon and delta) and phosphorylation of troponin I (TnI) in isolated cardiocytessurrogate

Angiotensin II receptor blockade prevents PKC epsilon activation and troponin I phosphorylation in diabetic rat hearts, suggesting a mechanism for its protective effect against diabetic cardiomyopathy.

Discussion

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Implication

AT1 blockade may mitigate diabetic cardiomyopathy via PKCε-TnI in rats; leaves open clinical translation and human trials.

Cite This Study

Malhotra et al. (1997) studied this question.

synapsesocial.com/papers/6a1c2f1b1567d2fc4d5fba0e https://doi.org/10.1161/01.res.81.6.1027

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Experimental Diabetes Is Associated With Functional Activation of Protein Kinase Cε and Phosphorylation of Troponin I in the Heart, Which Are Prevented by Angiotensin II Receptor Blockade

Structured PICO

Discussion

Implication

Cite This Study

Experimental Diabetes Is Associated With Functional Activation of Protein Kinase Cε and Phosphorylation of Troponin I in the Heart, Which Are Prevented by Angiotensin II Receptor Blockade

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider