Why the study?
Does alloxan-induced diabetes impair myocardial performance and recovery from anoxia in isolated rat hearts?
Population
Isolated perfused working rat heart preparation from alloxan-induced diabetic rats and normal rats
Comparison
Alloxan-induced diabetes vs Normal (non-diabetic) rat hearts
Design
Preclinical
Authors
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Diabetes may heighten anoxic vulnerability in experimental models; leaves open human relevance and needs clinical validation.
Does alloxan-induced diabetes impair myocardial performance and recovery from anoxia in isolated rat hearts?
Alloxan-induced diabetes depresses basal ventricular performance and impairs recovery from prolonged anoxia in isolated rat hearts, which can be mitigated by high glucose or insulin.
Ingebretsen et al. (1980) studied this question.
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