Key result
Insulin pretreatment protects diabetic rat hearts against ischemic dysfunction but fails to correct impaired microcirculation.
Why the study?
Does insulin treatment improve ventricular function and myocardial microcirculation in isolated perfused hearts from diabetic rats subjected to ischemia?
Population
Isolated perfused rat hearts from streptozotocin-induced diabetic rats
Comparison
Insulin treatment (injection) vs Control and untreated diabetic rat hearts
Design
Preclinical
Authors
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Suggests functional protection by insulin in diabetic ischemia models; leaves open microcirculatory targets and clinical translation.
Does insulin treatment improve ventricular function and myocardial microcirculation in isolated perfused hearts from diabetic rats subjected to ischemia?
Insulin pretreatment protects against ischemia-induced functional alterations in diabetic rat hearts, though it does not correct impaired myocardial microcirculation.
Mochizuki et al. (1984) studied Experimental diabetes mellitus. Insulin treatment vs. Untreated diabetic and non-diabetic controls was evaluated on Ventricular function and myocardial microcirculation. Insulin pretreatment protected against ischemia-induced functional alterations in isolated perfused hearts from diabetic rats, but did not correct impaired myocardial microcirculation.