Population
Hearts from control rats and streptozotocin-induced diabetic rats (65 mg/kg 48 h earlier)
Comparison
Insulin vs Hearts from untreated diabetic rats and control…
Design
Preclinical
Follow-up
45 minutes (perfusion duration)
Authors
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Supports insulin effects on myocardial lipolysis in diabetic rat models; leaves open human translation and clinical relevance.
Insulin directly stimulates myocardial lipoprotein lipase activity and VLDL triglyceride metabolism in diabetic rat hearts, partially through protein synthesis.
O'Looney et al. (1983) studied this question.
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