Population
Streptozotocin (STZ)-induced diabetic rats and control rats
Comparison
Perfusion of [(3)H]VLDL through isolated hearts vs Control rat hearts
Design
Preclinical
Authors
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May increase cardiac fatty acid delivery in diabetes; leaves open LPL targeting for cardiomyopathy prevention.
Diabetic rat hearts exhibit increased VLDL hydrolysis due to an enlarged luminal LPL pool, which may increase free fatty acid delivery and contribute to the development of diabetic cardiomyopathy.
Sambandam et al. (2000) studied this question.
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