Key result
Streptozotocin-induced diabetes in spontaneously hypertensive rats increased peak cardiac heparin-releasable lipoprotein lipase activity, counteracting the reduction associated with hypertension.
Diabetes-induced augmentation of cardiac LPL counteracts the reduction in enzyme activity associated with hypertension, potentially increasing free fatty acid delivery and contributing to severe cardiomyopathy.
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Diabetes may worsen cardiomyopathy via LPL in hypertension; hypothesis-generating and requires human validation before any clinical consideration.
Shepherd et al. (1998) studied Hypertension and Diabetes. Streptozotocin-induced diabetes vs. Non-diabetic controls was evaluated on Peak heparin-releasable lipoprotein lipase (LPL) activity. Streptozotocin-induced diabetes in spontaneously hypertensive rats increased peak cardiac heparin-releasable lipoprotein lipase activity, counteracting the reduction associated with hypertension.
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