Why the study?
Does the severity and duration of streptozotocin-induced diabetes affect cardiac lipoprotein lipase activity in Wistar rats?
Population
Wistar rats
Comparison
High or moderate dose of streptozotocin to… vs Control animals (non-diabetic Wistar rats)
Design
Preclinical
Follow-up
up to 12 weeks
Authors
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Severity-dependent LPL changes in diabetic rat hearts remain hypothesis-generating; human studies required before any clinical relevance.
Does the severity and duration of streptozotocin-induced diabetes affect cardiac lipoprotein lipase activity in Wistar rats?
Moderate, but not severe, streptozotocin-induced diabetes augments peak heparin-releasable cardiac lipoprotein lipase activity in rats, which can be normalized by insulin treatment.
Rodrigues et al. (1997) studied this question.
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