Population
Cardiomyocytes from rat hearts following acute (4-5 day) induction of diabetes with 100 mg/kg streptozotocin
Comparison
Induction of diabetes with 100 mg/kg… vs Control cardiomyocytes
Design
Preclinical
Follow-up
4-5 days
Authors
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May indicate post-transcriptional LPL defects in diabetic rat hearts; leaves open relevance to human cardiomyopathy.
Reduced lipoprotein lipase activity in diabetic rat cardiomyocytes is driven by post-transcriptional reduction in LPL synthesis and post-translational accumulation of inactive LPL protein.
Carroll et al. (1995) studied this question.
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