Key result
Chronic insulin treatment significantly increased adipose tissue lipoprotein lipase activity from 87 pkat/mg in untreated diabetic rats to 540 pkat/mg, correcting the diabetes-induced defect.
Population
Young male Sprague-Dawley rats with streptozocin-induced diabetes, n=23
Comparison
Chronic insulin treatment or acute insulin… vs Untreated diabetic rats and non-diabetic control…
Design
Preclinical, randomly divided into three groups
Follow-up
10 days
Authors
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Hypothesis-generating for LPL mRNA-targeted therapy in diabetic dyslipidemia; leaves open human translation.
Absolute Event Rate: 540% vs 87%
p-value: p=<0.01
Diabetes and insulin treatment regulate lipoprotein lipase expression through tissue-specific pretranslational, translational, and post-translational mechanisms in rats.
Tavangar et al. (1992) studied Diabetes mellitus (n=23). Insulin vs. Untreated diabetic rats was evaluated on Adipose tissue lipoprotein lipase (LPL) activity (pkat/mg) (p=<0.01). Chronic insulin treatment significantly increased adipose tissue lipoprotein lipase activity from 87 pkat/mg in untreated diabetic rats to 540 pkat/mg, correcting the diabetes-induced defect.
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