Why the study?
Does streptozotocin-induced insulin deficiency cause hypertriglyceridemia through decreased lipoprotein lipase activity in rats?
Population
2-month-old rats
Comparison
Streptozotocin-induced insulin deficiency vs Control rats
Design
Preclinical
Follow-up
1 week
Authors
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Impaired VLDL-TG removal beyond LPL changes drives hypertriglyceridemia in insulin-deficient rats; hypothesis-generating for human diabetic dyslipidemia.
Does streptozotocin-induced insulin deficiency cause hypertriglyceridemia through decreased lipoprotein lipase activity in rats?
In insulin-deficient rats, hypertriglyceridemia results from a VLDL-TG removal defect that is not fully explained by changes in total muscle and adipose tissue LPL activity.
Chen et al. (1979) studied this question.
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