Key result
Untreated ketotic diabetes was associated with a 44% decrease in mean postheparin plasma lipoprotein lipase activity compared to nondiabetic controls (p<0.001).
Why the study?
How does postheparin plasma lipoprotein lipase and hepatic lipase activity differ between diabetic patients and nondiabetic controls, and how does it relate to plasma triglyceride metabolism?
Case-Control (n=107)
How does postheparin plasma lipoprotein lipase and hepatic lipase activity differ between diabetic patients and nondiabetic controls, and how does it relate to plasma triglyceride metabolism?
Effect estimate: 44% decrease
p-value: p=<0.001
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May impair triglyceride clearance in diabetes; observational data leave causal role in VLDL turnover open.
Nikkilä et al. (1977) conducted a case-control in Diabetes Mellitus (n=107). Diabetes Mellitus vs. Nondiabetic controls was evaluated on Postheparin plasma lipoprotein lipase (LPL) activity (44% decrease, p=<0.001). Untreated ketotic diabetes was associated with a 44% decrease in mean postheparin plasma lipoprotein lipase activity compared to nondiabetic controls (p<0.001).
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