Key result
Post heparin plasma lipoprotein lipase activity showed no detectable abnormalities across various diabetic states, suggesting it plays a minor role in the pathogenesis of diabetic hyperlipemia.
Why the study?
Are there abnormalities in post heparin plasma lipoprotein lipase activity in patients with diabetes mellitus and hyperlipemia?
Observational (n=39)
Are there abnormalities in post heparin plasma lipoprotein lipase activity in patients with diabetes mellitus and hyperlipemia?
Abnormalities in the lipoprotein lipase system appear to play a minor role, if any, in the pathogenesis of diabetic hyperlipemia in humans.
Answers are grounded in this paper and cite their sources.
LPL activity unlikely to guide diabetic hyperlipemia management; leaves open alternative mechanisms for prospective study.
No detectable abnormalities or changes in the post heparin plasma lipoprotein lipase (LPL) activity were found in fifteen “insulin independent” (stable) or sixteen “insulin dependent” (labile) diabetics, with or without hyperlipemia, in four patients with ketoacidosis and hyperlipemia both during the acute phase and after recovery, in two subjects with insulin induced hypoglycemia, and in two patients with gross hyperlipemia and diabetes during marked fluctuations in lipid levels in one, and during correction of the hyperlipemia in the other. Abnormalities in the LPL system, as reflected in the post heparin plasma LPL activity, appear to play a minor role, if any, in the pathogenesis of diabetic hyperlipemia in man.
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Jones et al. (1966) conducted an observational in Diabetes Mellitus (n=39). Diabetes mellitus and hyperlipemia was evaluated on Post heparin plasma lipoprotein lipase (LPL) activity. Post heparin plasma lipoprotein lipase activity showed no detectable abnormalities across various diabetic states, suggesting it plays a minor role in the pathogenesis of diabetic hyperlipemia.
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