Why the study?
Does alloxan-induced diabetes alter post-heparin plasma lipase activities and lipoprotein profiles in rats?
Population
Male Sprague-Dawley rats weighing about 400 g with alloxan-induced diabetes and non-diabetic controls
Comparison
Heparin administration vs Non-diabetic control rats receiving the same…
Design
Preclinical
Follow-up
5 minutes post-heparin injection
Authors
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Hypothesis-generating in diabetic rat models; leaves open translation to human dyslipidemia or clinical practice.
Does alloxan-induced diabetes alter post-heparin plasma lipase activities and lipoprotein profiles in rats?
In experimental diabetic rats, decreased LPL and HTGL activities and impaired susceptibility of IDL to HTGL contribute to altered post-heparin plasma lipoprotein profiles, specifically increased IDL and decreased LDL.
Saheki et al. (1996) studied this question.
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