Why the study?
Does diabetes alter the release of lipoprotein lipase from rat cardiomyocytes?
Population
Isolated cardiac myocytes from rat hearts (streptozotocin-induced diabetic model)
Comparison
Induction of diabetes via streptozotocin and… vs Non-diabetic control rats
Design
Preclinical
Authors
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Impaired LPL release from diabetic rat cardiomyocytes is insulin-reversible; hypothesis-generating for mechanisms of dyslipidemia in human diabetes.
Does diabetes alter the release of lipoprotein lipase from rat cardiomyocytes?
Diabetes reduces the release of lipoprotein lipase from cardiomyocytes, potentially decreasing functional LPL activity at the capillary endothelium, an effect that is reversible by insulin.
Braun et al. (1991) studied this question.
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