Population
Freshly isolated and cultured cardiomyocytes from diabetic rats and control rats
Comparison
Combination of insulin and dexamethasone overnight vs Untreated cultured cardiomyocytes from diabetic…
Design
Preclinical
Follow-up
16 h (overnight)
Authors
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May support LPL restoration in diabetic cardiomyocytes; hypothesis-generating and leaves open in vivo or clinical translation.
In cultured cardiomyocytes from diabetic rats, the combination of insulin and dexamethasone stimulates and partially restores depressed lipoprotein lipase activity without altering LPL protein mass.
Ewart et al. (1999) studied this question.
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