Key result
Type 2 diabetes was associated with significantly lower fasting TRL-bound LPL activity compared to controls (70.1 vs 91.3 nmol NEFA/ml/h; P<0.001) and a blunted postprandial increase.
Why the study?
Does type 2 diabetes alter postprandial TRL-bound LPL activity compared to healthy controls?
Population
20 individuals (10 with type 2 diabetes and 10 controls)
Comparison
Ingestion of a lipid-rich meal vs Healthy controls
Design
Case-control
Follow-up
4 hours
Authors
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New nonheparin assay enables postprandial LPL time-course measurement; leaves open its clinical utility.
Observational (n=20)
Does type 2 diabetes alter postprandial TRL-bound LPL activity compared to healthy controls?
Absolute Event Rate: 70.1% vs 91.3%
p-value: p=<0.001
Pruneta‐Deloche et al. (2004) conducted an observational in Type 2 diabetes (n=20). Type 2 diabetes vs. Controls was evaluated on Fasting TRL-bound LPL-dependent TRL-TG hydrolysis (LTTH) (nmol NEFA/ml/h) (p=<0.001). Type 2 diabetes was associated with significantly lower fasting TRL-bound LPL activity compared to controls (70.1 vs 91.3 nmol NEFA/ml/h; P<0.001) and a blunted postprandial increase.
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