Key result
VLDL-bound LPL-dependent VLDL-TG hydrolysis (LVTH) was decreased by about 40% in heterozygous LPL-deficient patients and type 2 diabetics compared to controls, and correlated with VLDL conversion.
Why the study?
Is the ex vivo measurement of LVTH a physiologically relevant alternative to the postheparin lipolysis assay for assessing LPL activity?
Population
Control subjects, type 2 diabetics, and heterozygous or homozygous LPL-deficient patients, including a…
Comparison
Ex vivo measurement of VLDL-bound LPL-dependent… vs Postheparin lipolysis assay (PHLA)
Design
Cross-sectional
Authors
Loading...
LVTH supports LPL activity assessment without heparin; leaves open prospective validation as postheparin alternative.
Observational
Is the ex vivo measurement of LVTH a physiologically relevant alternative to the postheparin lipolysis assay for assessing LPL activity?
The ex vivo measurement of VLDL-bound LPL-dependent VLDL-TG hydrolysis (LVTH) is a physiologically relevant index that could serve as an alternative to the postheparin assay for assessing LPL activity.
Pruneta et al. (2001) conducted an observational in Type 2 diabetes, LPL deficiency. VLDL-bound LPL-dependent VLDL-TG hydrolysis (LVTH) assay vs. Postheparin lipolysis assay (PHLA) was evaluated on LVTH levels and correlation with VLDL conversion to IDL. VLDL-bound LPL-dependent VLDL-TG hydrolysis (LVTH) was decreased by about 40% in heterozygous LPL-deficient patients and type 2 diabetics compared to controls, and correlated with VLDL conversion.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: