Key result
Abdominal obesity in type 2 diabetes is linked to significantly higher postprandial triglyceride AUC.
Why the study?
Postprandial lipemia and LPL activity are important in accelerated atherosclerosis, but the effects of a liquid high-fat meal on postprandial lipid metabolism in type 2 diabetic patients with abdominal obesity and the influence of LPL PvuII polymorphisms were unclear.
Population
51 type 2 diabetic patients with abdominal obesity, 31 without abdominal obesity, and 39 controls
Comparison
Type 2 diabetic patients with abdominal obesity vs without abdominal obesity and controls; PvuII LPL polymorphisms compared within abdominal obesity group
Design
Cross-sectional study
Follow-up
8 hours postprandial
Authors
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Does not warrant practice change in T2D; leaves open whether targeting abdominal obesity improves postprandial lipids.
Cross-Sectional (n=121)
No
Mean Difference: 4.684 (95% CI 2.662–6.705)
p-value: p=<0.05
Wang et al. (2017) conducted a cross-sectional in Type 2 diabetes with abdominal obesity (n=121). Liquid high-fat meal vs. Type 2 diabetic patients without abdominal obesity and healthy controls was evaluated on Postprandial triglyceride area under the curve (AUC) (LSMD 4.684, 95% CI 2.662-6.705, p=<0.05). Abdominal obesity in type 2 diabetic patients significantly exacerbated postprandial lipid responses, including a higher triglyceride AUC (LSMD 4.684) after a liquid high-fat meal compared to those without abdominal obesity.
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