What is the clinical evidence from this study?

Study design: Cross-Sectional. Population: Insulin resistance (n=26). Intervention: Insulin resistance. Primary outcome: Adipose tissue lipoprotein lipase (LPL) activity (rho = -0.56, p=<0.01).

What question did this study set out to answer?

The study aims to explore how insulin resistance impacts the regulation of lipoprotein lipase in adipose tissue during the postprandial period.

February 1, 2002European Journal of Clinical Investigation

Insulin resistance affects the regulation of lipoprotein lipase in the postprandial period and in an adipose tissue‐specific manner

Q: What are the key findings of this study?

Insulin resistance was negatively correlated with postprandial adipose tissue lipoprotein lipase activity (rho = -0.56, P<0.01) and mRNA levels (rho = -0.50, P<0.02).

Q: What question did this study set out to answer?

The study aims to explore how insulin resistance impacts the regulation of lipoprotein lipase in adipose tissue during the postprandial period.

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Key result

Insulin resistance was negatively correlated with postprandial adipose tissue lipoprotein lipase activity (rho = -0.56, P<0.01) and mRNA levels (rho = -0.50, P<0.02).

Why the study?

Does insulin resistance affect the regulation of adipose tissue lipoprotein lipase in the postprandial period in adult nondiabetic individuals?

Population

26 adult nondiabetic individuals with a wide range of whole-body insulin-mediated glucose uptake

Design

Cross-sectional

Follow-up

4 hours

Authors

DPDaniel PanarottoUniversité de Sherbrooke PRPatrick RémillardUniversité de Sherbrooke LBL. BouffardUniversité de Sherbrooke

Discussion

Member takes

Overview

Insulin resistance may impair postprandial adipose LPL regulation in nondiabetics; hypothesis-generating for dyslipidemia mechanisms.

Key Points

The study aims to explore how insulin resistance impacts the regulation of lipoprotein lipase in adipose tissue during the postprandial period.
26 adult nondiabetic individuals (12 women and 14 men) were studied.
Adipose tissue samples and plasma were collected at 4 hours into a standardized meal.
Insulin suppression test assessed whole-body insulin-mediated glucose uptake.
Postprandial triglyceride levels were inversely correlated with adipose tissue LPL mRNA (rho = -0.43, P < 0.03).
Adipose tissue LPL heparin-releasable activity showed a stronger negative correlation with triglyceride excursions (rho = -0.58, P < 0.01).
SSPG concentrations correlated negatively with adipose tissue LPL mRNA (rho = -0.50, P < 0.02) and activity (rho = -0.56, P < 0.01).

Study Design

Type

Cross-Sectional (n=26)

Structured PICO

Does insulin resistance affect the regulation of adipose tissue lipoprotein lipase in the postprandial period in adult nondiabetic individuals?

Population

26 adult nondiabetic individuals (12 women, 14 men) evaluated for the relationship between insulin resistance and adipose tissue lipoprotein lipase during the postprandial period.

Exposure

Standardized meal profile administered in the fasting state, with abdominal subcutaneous fat biopsy and post-heparin plasma collection at 4 hours

Outcome

Relationship between insulin resistance (steady-state plasma glucose) and adipose tissue LPL mRNA and activity, as well as postprandial triglyceride excursionssurrogate

Main Result

Effect estimate: rho = -0.56

p-value: p=<0.01

Insulin resistance is associated with impaired regulation of adipose tissue lipoprotein lipase in the postprandial period, potentially contributing to atherogenic dyslipidemia.

Cite This Study

Panarotto et al. (2002) conducted a cross-sectional in Insulin resistance (n=26). Insulin resistance was evaluated on Adipose tissue lipoprotein lipase (LPL) activity (rho = -0.56, p=<0.01). Insulin resistance was negatively correlated with postprandial adipose tissue lipoprotein lipase activity (rho = -0.56, P<0.01) and mRNA levels (rho = -0.50, P<0.02).

synapsesocial.com/papers/6a226a2db65eef78bdff5f4d https://doi.org/10.1046/j.1365-2362.2002.00945.x

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February 1, 2002European Journal of Clinical Investigation

Insulin resistance affects the regulation of lipoprotein lipase in the postprandial period and in an adipose tissue‐specific manner

View Full Paper

Ask AI

Bookmark

Key result

Insulin resistance was negatively correlated with postprandial adipose tissue lipoprotein lipase activity (rho = -0.56, P<0.01) and mRNA levels (rho = -0.50, P<0.02).

Why the study?

Does insulin resistance affect the regulation of adipose tissue lipoprotein lipase in the postprandial period in adult nondiabetic individuals?

Population

26 adult nondiabetic individuals with a wide range of whole-body insulin-mediated glucose uptake

Design

Cross-sectional

Follow-up

4 hours

Authors

DPDaniel PanarottoUniversité de Sherbrooke PRPatrick RémillardUniversité de Sherbrooke LBL. BouffardUniversité de Sherbrooke

Discussion

Member takes

Overview

Insulin resistance may impair postprandial adipose LPL regulation in nondiabetics; hypothesis-generating for dyslipidemia mechanisms.

Key Points

The study aims to explore how insulin resistance impacts the regulation of lipoprotein lipase in adipose tissue during the postprandial period.
26 adult nondiabetic individuals (12 women and 14 men) were studied.
Adipose tissue samples and plasma were collected at 4 hours into a standardized meal.
Insulin suppression test assessed whole-body insulin-mediated glucose uptake.
Postprandial triglyceride levels were inversely correlated with adipose tissue LPL mRNA (rho = -0.43, P < 0.03).
Adipose tissue LPL heparin-releasable activity showed a stronger negative correlation with triglyceride excursions (rho = -0.58, P < 0.01).
SSPG concentrations correlated negatively with adipose tissue LPL mRNA (rho = -0.50, P < 0.02) and activity (rho = -0.56, P < 0.01).

Study Design

Type

Cross-Sectional (n=26)

Structured PICO

Does insulin resistance affect the regulation of adipose tissue lipoprotein lipase in the postprandial period in adult nondiabetic individuals?

Population

26 adult nondiabetic individuals (12 women, 14 men) evaluated for the relationship between insulin resistance and adipose tissue lipoprotein lipase during the postprandial period.

Exposure

Standardized meal profile administered in the fasting state, with abdominal subcutaneous fat biopsy and post-heparin plasma collection at 4 hours

Outcome

Relationship between insulin resistance (steady-state plasma glucose) and adipose tissue LPL mRNA and activity, as well as postprandial triglyceride excursionssurrogate

Main Result

Effect estimate: rho = -0.56

p-value: p=<0.01

Insulin resistance is associated with impaired regulation of adipose tissue lipoprotein lipase in the postprandial period, potentially contributing to atherogenic dyslipidemia.

Cite This Study

synapsesocial.com/papers/6a226a2db65eef78bdff5f4d https://doi.org/10.1046/j.1365-2362.2002.00945.x

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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