Key result
Fasting lipoprotein lipase mass levels independently predicted the area under the curve of postprandial triglycerides (β = 0.65, P < 0.01).
Why the study?
Can fasting LPL levels predict postprandial triglyceride increments in subjects with fasting normotriglyceridemia?
Observational (n=17)
Can fasting LPL levels predict postprandial triglyceride increments in subjects with fasting normotriglyceridemia?
Fasting LPL levels can independently predict postprandial triglyceride increments in subjects with normal fasting triglycerides, offering a potential clinical marker for atherogenic risk without requiring a fat load test.
May support fasting LPL mass for postprandial TG risk assessment; hypothesis-generating and should not yet change practice.
BACKGROUND: Although a postprandial increment in triglyceride (TG) levels is considered to be a risk factor for atherogenesis, tests (e.g., fat load) to assess postprandial changes in TG levels cannot be easily applied to clinical practice. Therefore, fasting markers that predict postprandial TG states are needed to be developed. One current candidate is lipoprotein lipase (LPL) protein, a molecule that hydrides TGs. This study investigated whether fasting LPL levels could predict postprandial TG levels. METHODS: A total of 17 subjects (11 men, 6 women, mean age 52 ± 11 years) with normotriglyceridemia during fasting underwent the meal test. Several fasting parameters, including LPL, were measured for the area under the curve of postprandial TGs (AUC-TG). RESULTS: The subjects' mean fasting TG level was 1.30 mmol/l, and their mean LPL level was 41.6 ng/ml. The subjects' TG levels increased after loading (they peaked after two postprandial hours). Stepwise multiple regression analysis demonstrated that fasting TG levels were a predictor of the AUC-TG. In addition, fasting LPL mass levels were found to be a predictor of the AUC-TG (β = 0.65, P < 0.01), and this relationship was independent of fasting TG levels. CONCLUSION: Fasting LPL levels may be useful to predict postprandial TG increment in this population.
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Tsuzaki et al. (2015) conducted an observational in Fasting normotriglyceridemia (n=17). Fasting lipoprotein lipase (LPL) protein levels was evaluated on Area under the curve of postprandial TGs (AUC-TG) (β = 0.65, p=< 0.01). Fasting lipoprotein lipase mass levels independently predicted the area under the curve of postprandial triglycerides (β = 0.65, P < 0.01).
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