Key result
In STZ-induced diabetic rats, severe hyperlipidemia was associated with a dramatic decline in VLDL-R protein in skeletal muscle (>90%) and heart (~50%), which was restored by insulin in vitro.
Population
Rats with streptozotocin (STZ)-induced diabetes and rat myoblast cells
Comparison
Streptozotocin-induced diabetes and serum… vs Non-diabetic state and serum deprivation without…
Design
Preclinical
Follow-up
28 days
Authors
Loading...
Animal data link VLDL-R loss to diabetic hyperlipidemia; leaves open human relevance and therapeutic implications.
The combination of VLDL receptor deficiency and reduced plasma lipoprotein lipase activity may drive severe hyperlipidemia in insulin-deficient diabetes.
Iwasaki et al. (2005) studied Streptozotocin (STZ)-induced diabetes and hyperlipidemia. Streptozotocin (STZ)-induced diabetes (insulin deficiency) vs. Normal state (implied) was evaluated on VLDL-R expression in heart and skeletal muscle, and hyperlipidemia. In STZ-induced diabetic rats, severe hyperlipidemia was associated with a dramatic decline in VLDL-R protein in skeletal muscle (>90%) and heart (~50%), which was restored by insulin in vitro.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: