Population
Working hearts isolated from control rats and diabetic rats 2 weeks following streptozotocin (STZ) injection
Comparison
Perfusion with diabetic lipoproteins vs Perfusion with control lipoproteins in control…
Design
Preclinical
Follow-up
2 weeks post-STZ injection
Authors
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Does not yet inform clinical management of diabetic cardiomyopathy; leaves open whether early lipoprotein-TAG oxidation precedes dysfunction in humans.
In early type 1 diabetic rat hearts, TAG-rich lipoprotein metabolism is increased and glucose oxidation is decreased, leading to intracardiomyocyte TAG accumulation prior to impaired cardiac performance.
Rhys Evans (2008) studied this question.
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