Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
June 1, 1982AJP Heart and Circulatory Physiology

Endogenous triacylglycerol metabolism in diabetic heart

View Full Paper
Ask AI
Bookmark
Share

Authors

DPD. J. PaulsonWave Life Sciences (United States)MCM. F. CrassTexas Tech University

Discussion

Loading...

Member takes

Implication

Controlled animal study reveals triacylglycerol accumulation in diabetic rat hearts, indicating that circulating fatty acids and glucose drive synthesis while inhibiting lipolysis.

Key Points

  • To determine the metabolic mechanisms governing endogenous triacylglycerol synthesis, lipolysis, and oxidation in the diabetic rat heart under varying substrate environments.
  • Perfused working hearts isolated from control and 12-day streptozotocin-induced diabetic rats under normal (9 mM glucose, 0.5 mM free fatty acids) or diabetic (27 mM glucose, 1.2 mM free fatty acids) substrate conditions.
  • Quantified triacylglycerol synthesis via [9,10-3H]palmitate incorporation and assessed lipolysis by tracking [1-14C]palmitate clearance alongside synthesis-lipolysis mass balances.
  • Diabetic hearts perfused with diabetic concentrations maintained elevated triacylglycerol content via enhanced synthesis and reduced or unchanged lipolysis, while triacylglycerol fatty acid oxidation remained unimpaired.
  • Diabetic hearts switched to normal substrate conditions exhibited markedly enhanced lipolysis and triacylglycerol fatty acid oxidation compared to diabetic conditions.

Cite This Study

Paulson et al. (1982) studied this question.

synapsesocial.com/papers/6a71b23f2163a0a01bc5bb7ahttps://doi.org/10.1152/ajpheart.1982.242.6.h1084
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Regulation of Triacylglycerol Lipolysis in the Perfused Hearts of Normal and Diabetic Rats1983 · 27 citations
  2. 2Accelerated triacylglycerol turnover kinetics in hearts of diabetic rats include evidence for compartmented lipid storage2005 · 51 citations
  3. 3Metabolism of very-low-density lipoprotein and chylomicrons by streptozotocin-induced diabetic rat heart: effects of diabetes and lipoprotein preference2008 · 10 citations
  4. 4Myocardial metabolism of triacylglycerol‐rich lipoproteins in type 2 diabetes2009 · 11 citations
  5. 5Lipolysis in isolated myocardial cells from diabetic rat hearts1985 · 30 citations