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May 12, 2009The Journal of PhysiologyOpen Access

Myocardial metabolism of triacylglycerol‐rich lipoproteins in type 2 diabetes

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Population

ZDF rat model of type 2 diabetes (obese diabetic and lean littermate control rats)

Comparison

Perfusion of isolated hearts with… vs Perfusion of isolated hearts with VLDL and CM…

Design

Preclinical

Authors

RERhys EvansUniversité Claude Bernard Lyon 1

Discussion

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Implication

No immediate clinical implications; extends preclinical TAG metabolism insights but leaves human relevance open.

Structured PICO

P
Population
ZDF rat model of type 2 diabetes (obese diabetic and lean littermate control rats)
I
Intervention
Perfusion of isolated hearts with very-low-density lipoprotein (VLDL) and chylomicrons (CM) from diabetic rats
C
Comparator
Perfusion of isolated hearts with VLDL and CM from control rats
O
Outcome
Metabolic fate of the lipoprotein triacylglycerol (TAG) and contractile functionsurrogate

Alterations in cardiac TAG-rich lipoprotein metabolism in type 2 diabetes are driven by changes in both the myocardium and the lipoprotein particle, with decreased contractile function potentially linked to altered TAG-fatty acid oxidation rather than lipid accumulation.

Cite This Study

Rhys Evans (2009) studied this question.

synapsesocial.com/papers/6a8091028ae067bd3b703e39https://doi.org/10.1113/jphysiol.2009.173542
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Endogenous triacylglycerol metabolism in diabetic heart1982 · 86 citations
  2. 2Regulation of lipoprotein lipase in the diabetic rat.1992 · 68 citations
  3. 3Differential modulation of citrate synthesis and release by fatty acids in perfused working rat hearts2004 · 34 citations
  4. 4Abnormal mechanical function in diabetes1996 · 87 citations
  5. 5Routes of FA delivery to cardiac muscle: modulation of lipoprotein lipolysis alters uptake of TG-derived FA2003 · 140 citations