Mechanisms for Development of Diabetic Hypertriglyceridemia in Streptozotocin-Treated Rats EFFECT OF DIET AND DURATION OF INSULIN DEFICIENCY
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Population
Female Sprague-Dawley rats, 175-200 g each
Comparison
Streptozotocin 75 mg/kg IV to induce insulin… vs Control rats injected with citrate buffer, fed…
Design
Preclinical, the source of the tissue was not known to the microscopist at the…
Follow-up
24 hours (acute) or 7 days (chronic)
Authors
Discussion
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Implication
Distinguishes acute secretion-driven from chronic removal-defect hypertriglyceridemia in insulin deficiency; leaves open translation to human diabetes.
Structured PICO
P
Population
Female Sprague-Dawley rats, 175-200 g each
I
Intervention
Streptozotocin (SZ) 75 mg/kg IV to induce insulin deficiency, combined with either Diet A (fat-free, high carbohydrate) or Diet B (high fat, low carbohydrate), for acute (24 h) or chronic (7 days) duration
C
Comparator
Control rats injected with citrate buffer, fed either Diet A or Diet B
O
Outcome
Plasma triglyceride (TG) levels, TG entry rate into plasma, and hepatocyte Golgi VLDL content and sizesurrogate
Cite This Study
Reaven et al. (1974) studied this question.
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