Why the study?
Does severe hypertriglyceridemia caused by LPL deficiency impair glucose tolerance and insulin response in mice?
Population
Lipoprotein lipase-deficient mice with severe hypertriglyceridemia
Comparison
LPL deficiency (severe hypertriglyceridemia model) vs Wild-type mice of a similar age
Design
Preclinical
Authors
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No immediate clinical implications from mouse data; leaves open whether LPL deficiency impairs human glucose homeostasis.
Does severe hypertriglyceridemia caused by LPL deficiency impair glucose tolerance and insulin response in mice?
Severe hypertriglyceridemia in LPL-deficient mice leads to a decreased early insulin response and age-dependent changes in glucose tolerance, suggesting patients with LPL deficiency may require specific glucose homeostasis testing.
Ding et al. (2010) studied this question.
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